PCORI Board of Governors Approves $71.5 Million


WASHINGTON, DC – The Board of Trustees of the Patient-Centered Outcomes Research Institute (PCORI) today approved multiple grant listings totaling approximately $71.5 million to support 12 new comparative studies on the effectiveness (CER) and methods. Two of the studies focus on priority topics for PCORI funding, namely reducing maternal morbidity and mortality and improving care for people with intellectual and developmental disabilities.

In addition, the PCORI Board of Directors approved nearly $9 million for three projects aimed at facilitating the uptake of PCORI-funded research results in the treatment of urinary incontinence (UI), care patients with sickle cell disease and mental health care.

The Board also approved PCORI’s issuance of two new funding opportunities, one focused on health systems strategies to reduce disparities in the management and control of hypertension and the other on building an evidence base to inform effective stakeholder engagement strategies in patient-centred REC.

“These latest funding awards reflect PCORI’s commitment to solving our nation’s most critical health issues by funding research that aims to improve health care delivery and health outcomes in real-world settings,” said said PCORI Executive Director Nakela L. Cook, MD, MPH. the data generated by these and other PCORI-funded studies will help patients and those who care for them make more informed decisions about their care and inform the national dialogue on health and centered health care. the patient.

New REC aims to improve results in key areas

An ERC study on maternal health will compare ways to improve early detection and management of postpartum complications such as hypertension and depression, including remote monitoring interventions and trauma-informed care. The study will focus on people at risk of experiencing inequalities in maternal health outcomes, including black and Hispanic people, people living in rural areas, and those with Medicaid or without insurance.

Another ERC study is investigating whether the drugs most often prescribed for attention deficit/hyperactivity disorder (ADHD) are as effective for children who also have an autism diagnosis as for children without a diagnosis of autism. autism. The study will also assess the effectiveness of second-line drugs.

Three REB studies will compare how well non-surgical interventions improve UI. Two will compare treatment with onabotulinumtoxinA injections, one looking at different doses of the drug in older women for whom anticholinergic drugs – long considered standard treatment – ​​are no longer recommended due to an increased risk of dementia, and the second comparing onabotulinumtoxinA injections with the oral beta-agonist drug mirabegron in women who have tried more conservative treatments without success. The third study will compare electronic co-management of UI to care management provided by an advanced practice provider.

Implementation projects facilitate the dissemination and adoption of useful evidence

Projects aimed at facilitating the uptake of PCORI-funded research results will focus on:

  • Using a health system’s electronic health records and self-care program to virtually reach and treat women affected by UI who have never sought care before.
  • Optimize sickle cell care for approximately 3,500 patients in nine states by deploying an infusion center set-up toolkit and accelerating the set-up of these specialty centers through a facilitation network.
  • Implement a program that matches patients with therapists based on patients’ top mental health issues and therapist strengths through electronic health records at approximately 50 mental health centers reaching 60,000 patients in 30 states.

Details of these studies and all other studies and projects approved for funding can be found on the PCORI website. All funding awards have been approved pending a review of activities and programs by PCORI staff and issuance of formal award contracts. With these latest awards, PCORI will have invested more than $3.2 billion to fund patient-centered REC and support other projects designed to improve REC methods and the infrastructure needed to conduct REC rigorously and effective.

Targeted funding to improve research engagement, hypertension disparities

In addition to approving new award lists, the Board also approved PCORI’s development of two PCORI Targeted Funding Announcements to be released in May. A funding announcement will provide up to $50 million to fund studies comparing the effectiveness of strategies health systems can adopt to reduce disparities in the management and control of hypertension.

Another opportunity will provide up to $36 million to fund research that advances the science of engagement – ​​the systematic study of methods and outcomes of engaging patients and diverse stakeholders as partners in the research process to improve the quality of patient-centred REC. The funded fellowships will address important evidence gaps, such as which engagement techniques are most effective among historically underrepresented populations and how best to define or measure engagement.

“Over the past decade, PCORI has transformed the way research is conducted by requiring meaningful involvement and partnership with patients and other stakeholders in the research it funds, from planning to carrying out the study until the results of the study are released,” Cook said. “With this targeted funding announcement, PCORI will bring together the rigorous evidence available to improve research engagement across the healthcare enterprise and advance our national health priorities.”


The Patient-Centered Outcomes Research Institute (PCORI) is an independent, nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers, and clinicians with the evidence-based information needed to improve the health. care decisions. PCORI is committed to continuously seeking input from a wide range of stakeholders to guide its work.

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